Package: LOCOM2
Type: Package
Title: A Logistic Regression Model for Testing Microbial Differential
        Abundance
Version: 1.1
Date: 2026-10-29
Authors@R: person(given = "Yi-Juan",
                      family = "Hu",
                      role = c("aut", "cre"),
                      email = "yijuanhu@bicmr.pku.edu.cn")
Maintainer: Yi-Juan Hu <yijuanhu@bicmr.pku.edu.cn>
Description: Testing differential abundance at individual taxa and in a whole microbial community. The tests are based on the log-ratio of relative abundances. The tests accommodate continuous, discrete (binary, categorical), and multivariate traits, and allow adjustment of confounders. For more details see He (2026) <doi:10.64898/2026.04.07.716976>. This package also includes the 'com2seq' function that combines two sequencing datasets (e.g., from 16S marker-gene and shotgun sequencing) for integrative analysis of differential abundance. For more details see <doi:10.1080/01621459.2025.2516205>.
License: GPL (>= 2)
RoxygenNote: 7.3.2
Depends: R (>= 3.5.0)
Imports: Rcpp (>= 1.0.11), stats, permute, parallel, BiocParallel,
        matrixStats, abind, car
LinkingTo: Rcpp, RcppArmadillo
Suggests: testthat, survival
URL: https://github.com/yijuanhu/LOCOM2
BugReports: https://github.com/yijuanhu/LOCOM2/issues
Encoding: UTF-8
LazyData: true
NeedsCompilation: yes
Packaged: 2026-10-29 11:56:29 UTC; yhu30
Author: Yi-Juan Hu [aut, cre]
Repository: CRAN
Date/Publication: 2026-10-29 12:50:02 UTC
